Reviewed by Dr. Brent Boyse

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If you’ve noticed your hair thinning or your scalp showing more than usual, you’ve likely explored hair regrowth options. But regenerative medicine has transformed hair restoration, and platelet-rich fibrin (PRF) now leads the way.

Table of Contents

What Is PRF Hair Restoration?

PRF (platelet-rich fibrin) uses your body’s own blood components to trigger natural hair regrowth. After a small blood draw, the sample is spun in a centrifuge to isolate platelets, white blood cells, fibrin, and stem cells. This concentrated serum is then injected into thinning areas of your scalp.

These regenerative cells release growth factors that:

  • Wake dormant hair follicles
  • Increase blood flow
  • Support stronger, thicker strands

PRF offers a natural, drug-free solution with minimal downtime and long-lasting results.

PRF vs. PRP: What’s the Difference?

PRP (platelet-rich plasma) was the first regenerative hair treatment to gain popularity, but PRF has become the next-generation option.

Before comparing, let’s define how they differ:

FeaturePRPPRF
AdditivesUses anticoagulantsNo additives
Growth Factor ReleaseImmediate, short burstSlow, sustained release
CompositionMostly plateletsPlatelets, stem cells, and white blood cells
ResultsGradual improvementStronger, longer-lasting results

PRF works deeper and longer, creating a stronger environment for regrowth. Many patients who plateaued with PRP see renewed progress after switching to PRF.

PRF vs. Exosome Injections

Exosome therapy is another regenerative technique that delivers microscopic “messenger” vesicles to the scalp. These vesicles send growth signals to nearby cells, supporting new tissue and follicle activity.

However, exosomes are typically lab-derived and not always autologous (from your own body). While they can enhance healing, they don’t replace the powerful stem cells and fibrin structure PRF naturally provides.

PRF vs. Hair Transplant Surgery

Hair transplant surgery redistributes existing follicles from one area to another. It’s effective for restoring coverage in bald areas but doesn’t stop ongoing thinning or improve scalp health.

PRF helps preserve existing follicles and may delay or enhance transplant results. Many surgeons now use PRF before and after transplants to:

  • Strengthen transplanted follicles
  • Improve blood supply
  • Speed healing and reduce shock loss.

If you are planning on getting hair transplants out of the country, we can support you pre and post surgery with PRF therapy. 

Ideal Candidates for PRF Hair Restoration

PRF hair restoration is a great fit for both men and women experiencing:

  • Early to moderate hair thinning
  • Androgenetic alopecia (male or female pattern baldness)
  • Post-transplant maintenance or preparation
  • Hair loss due to hormonal or stress-related factors

You may not be a candidate if you have a blood disorder, active infection, or take certain blood-thinning medications. Dr. Boyse will review your health history to tailor your plan safely.

The Natural Advantage of PRF Hair Restoration

Among today’s hair loss treatments, PRF stands out for its safety, simplicity, and regenerative power. It uses your body’s own cells to restore a healthier scalp environment, without the need for surgery or synthetic chemicals. 

Whether you’re looking to slow thinning, prepare for a transplant, or support post-surgical recovery, PRF offers a proven way to boost density and confidence.

Dr. Brent Boyse offers PRF hair restoration along with a full range of aesthetic treatments at our Superstition Springs location. 

To book an appointment at our Mesa location, call (480) 830-5866 or visit us at 6755 E. Superstition Springs Blvd. Suite 103 Mesa, AZ 85206.

FAQ

How many PRF treatments do I need for hair growth?

Most patients benefit from 2–3 sessions spaced 4–6 weeks apart, followed by yearly maintenance. Because this is a minimally invasive procedure, treatments fit easily into your routine without major downtime.

Is PRF better than PRP for hair restoration?

PRF delivers a higher concentration of growth factors and releases them slowly, encouraging stronger follicle activity and collagen production over time. This leads to smoother scalp texture and natural-looking results that continue to improve for months after treatment.

Can PRF regrow hair in bald areas?

PRF works best in thinning areas with active follicles. It helps stimulate regrowth where the scalp still has potential for renewal. For completely bald areas, your doctor may recommend combining PRF injections with other non-surgical treatments or supportive therapies as part of your treatment plan.

How soon will I see results from PRF hair restoration?

Most patients start noticing new growth and thicker hair within 3–6 months after their first session.

Can PRF be combined with other treatments?

PRF can be combined with exosome therapy, stem cell therapy, microneedling, or topical solutions for enhanced results. Each treatment plan is customized based on the degree of thinning hair, scalp health, and individual goals.